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Review Article

Antimicrobial Resistance (AMR): Chemistry Solutions Beyond Traditional Antibiotics

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Abstract

Antimicrobial resistance (AMR) has emerged as the most critical threat to global health, contributing to over 1.2 million deaths annually and projected to cause up to 10 million deaths per year by 2050 if left unaddressed. Traditional antibiotic development focused on structural modification of existing molecules has failed to match the rapid evolution of resistance mechanisms. This review underscores a paradigm shift, positioning chemistry not as a supplementary tool but as a transformative force in AMR mitigation. We explore a spectrum of chemistry-driven strategies, including efflux pump inhibitors that restore antibiotic efficacy by over 80% in vitro, β-lactamase inhibitors with 50–90% re-sensitization capacity, and antisense oligonucleotides demonstrating >70% gene silencing efficiency for resistance determinants like blaCTX-M and ndm-1. Novel CRISPR-based antimicrobials delivered via chemically engineered nanoparticles have shown the potential to restore colistin susceptibility in >60% of resistant strains. Furthermore, smart nanomaterials and targeted delivery systems have achieved up to 5-fold increases in localized drug concentration, significantly reducing off-target effects. These precision-based approaches enabled by synthetic chemistry, materials science, and molecular engineering offer versatile, adaptable, and resistance-mitigating solutions. We highlight regulatory challenges, scalability concerns, and the imperative for interdisciplinary collaboration to bridge lab innovations with clinical implementation. Chemistry remains central in the quest for sustainable, long-term solutions to AMR.

Keywords:

Antimicrobial Resistance (AMR) Antivirulence Agents Chemical Strategies CRISPR-Based Gene Editing Tools Host–Pathogen Interactions

Article information

Journal

Journal of Life Science and Public Health

Volume (Issue)

1(1), (2025)

Pages

10-23

Published

12-08-2025

How to Cite

Owosagba, V. A., Stephen, J., Eke, B. G., Ebiala, F. I., Okonkwo, C. O., Alli, O. O., Ajaero, A. V., Hammed, M. A., & Yerima, S. R. (2025). Antimicrobial Resistance (AMR): Chemistry Solutions Beyond Traditional Antibiotics. Journal of Life Science and Public Health, 1(1), 10-23. https://doi.org/10.69739/jlsph.v1i1.784

References

global health issues to track in 2021. (n.d.). Retrieved July 14, 2025, from https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021

Abdelhamid, A. G., & Yousef, A. E. (2023). Combating Bacterial Biofilms: Current and Emerging Antibiofilm Strategies for Treating Persistent Infections. Antibiotics, 12(6), 1005. https://doi.org/10.3390/antibiotics12061005

Agha, A. S. A., Al-Samydai, A., & Aburjai, T. (2025). New frontiers in CRISPR: Addressing antimicrobial resistance with Cas9, Cas12, Cas13, and Cas14. Heliyon, 11(2), e42013. https://doi.org/10.1016/j.heliyon.2025.e42013

Ahmad, N., Joji, R. M., Kumar, V., Pagani, L., & Shahid, M. (2025). Editorial: Evolution, molecular mechanisms and the strategies to combat antimicrobial resistance (AMR): a One Health approach. Frontiers in Cellular and Infection Microbiology, 15, 1582613. https://doi.org/10.3389/fcimb.2025.1582613

Alum, E. U., Gulumbe, B. H., Izah, S. C., Uti, D. E., Aja, P. M., Igwenyi, I. O., & Offor, C. E. (2025). Natural product-based inhibitors of quorum sensing: A novel approach to combat antibiotic resistance. Biochemistry and Biophysics Reports, 43, 102111. https://doi.org/10.1016/j.bbrep.2025.102111

Andrades-Lagos, J., Campanini-Salinas, J., Pedreros-Riquelme, A., Mella, J., Choquesillo-Lazarte, D., Zamora, P. P., Pessoa-Mahana, H., Burbulis, I., & Vásquez-Velásquez, D. (2023). Design, Synthesis, and Structure-Activity Relationship Studies of New Quinone Derivatives as Antibacterial Agents. Antibiotics, 12(6), 1065. https://doi.org/10.3390/antibiotics12061065

Antimicrobial resistance. (n.d.). Retrieved July 14, 2025, from https://www.who.int/health-topics/antimicrobial-resistance

Ayomide, I. T., Promise, L. O., Christopher, A. A., Okikiola, P. P., Esther, A. D., Favour, A. C., Agbo, O. S., Sandra, O.-A., Chiagozie, O. J., Precious, A. C., & Ugonna, U. K. (2024). The Impact of Antimicrobial Resistance on Co-INFECTIONS: Management Strategies for HIV, TB and Malaria. International Journal of Pathogen Research, 13(6), 117–128. https://doi.org/10.9734/ijpr/2024/v13i6326

Baindara, P. (2025). Antimicrobial Peptides: An Emerging Hope in the Era of New Infections and Resistance. Antibiotics, 14(6), 546. https://doi.org/10.3390/antibiotics14060546

Bedair, H. M., Hamed, M., & Mansour, F. R. (2024). New emerging materials with potential antibacterial activities. Applied Microbiology and Biotechnology, 108(1), 515. https://doi.org/10.1007/s00253-024-13337-6

Bremmer, D. N., Bauer, K. A., Pouch, S. M., Thomas, K., Smith, D., Goff, D. A., Pancholi, P., & Balada-Llasat, J.-M. (2016). Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections. Antimicrobial Agents and Chemotherapy, 60(11), 6892–6895. https://doi.org/10.1128/AAC.00981-16

da Silva, L. C. N., da Silva, M. V., & Correia, M. T. dos S. (2017). Editorial: New Frontiers in the Search of Antimicrobials Agents from Natural Products. Frontiers in Microbiology, 8, 210. https://doi.org/10.3389/fmicb.2017.00210

de Oliveira, K. B. S., Leite, M. L., Melo, N. T. M., Lima, L. F., Barbosa, T. C. Q., Carmo, N. L., Melo, D. A. B., Paes, H. C., & Franco, O. L. (2024). Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections. Antibiotics, 13(11), 1042. https://doi.org/10.3390/antibiotics13111042

Desai, N. (2012). Challenges in Development of Nanoparticle-Based Therapeutics. The AAPS Journal, 14(2), 282. https://doi.org/10.1208/s12248-012-9339-4

Dik, J.-W. H., Friedrich, A. W., Nathwani, D., & Sinha, B. (2017). Combating the Complex Global Challenge of Antimicrobial Resistance: What can Antimicrobial Stewardship Contribute? Infectious Disease Reports, 9(1), 7158. https://doi.org/10.4081/idr.2017.7158

Ding, K., Liao, M., Wang, Y., & Lu, J. R. (2025). Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications. Gels, 11(6), 420. https://doi.org/10.3390/gels11060420

Du, J.-J., Zhang, R.-Y., Jiang, S., Xiao, S., Liu, Y., Niu, Y., Zhao, W.-X., Wang, D., & Ma, X. (2025). Applications of cell penetrating peptide-based drug delivery system in immunotherapy. Frontiers in Immunology, 16. https://doi.org/10.3389/fimmu.2025.1540192

Duffey, M., Jumde, R. P., da Costa, R. M. A., Ropponen, H.-K., Blasco, B., & Piddock, L. J. V. (2024). Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps. ACS Infectious Diseases, 10(5), 1458–1482. https://doi.org/10.1021/acsinfecdis.4c00091

Ekins, S., Clark, A. M., Swamidass, S. J., Litterman, N., & Williams, A. J. (2014). Bigger Data, Collaborative Tools and the Future of Predictive Drug Discovery. Journal of Computer-Aided Molecular Design, 28(10), 997–1008. https://doi.org/10.1007/s10822-014-9762-y

Elechi, K. W., Igboaka, C. D., Tiamiyu, B. B., Ugbor, M.-J. E., Arthur, C., Ezeh, O. M., Faderin, E. A., Olowookere, A., Lawal, O. P., Elechi, K. W., Igboaka, C. D., Tiamiyu, B. B., Ugbor, M.-J. E., Arthur, C., Ezeh, O. M., Faderin, E. A., Olowookere, A., & Lawal, O. P. (2025). Phytochemical Screening of Ficus globosa Latex (Moraceae) as a Source of Novel Antimicrobial Compounds. Path of Science, 11(3), Article 3. https://doi.org/10.22178/pos.115-28

Fadaka, A. O., Sibuyi, N. R. S., Madiehe, A. M., & Meyer, M. (2021). Nanotechnology-Based Delivery Systems for Antimicrobial Peptides. Pharmaceutics, 13(11), 1795. https://doi.org/10.3390/pharmaceutics13111795

Folorunsho, S. (n.d.). The Role of Social Determinants of Health in Shaping Racial and Disability Disparities Among Older Adults in the United States. Journal of Aging & Social Policy, 1–17. https://doi.org/10.1080/08959420.2025.2528584

Folorunsho, S., Ajayi, V., & Abdulrazaq, O. (2024). Juvenile delinquency as a contemporary issue in Nigeria: Understanding the impacts of parenting styles, single parenting and marital discord. African Journal of Social Issues, 7(1), Article 1. https://doi.org/10.4314/ajosi.v7i1.8

Folorunsho, S., Ajayi, V., Sanmori, M., Suleiman, M., Abdullateef, R., & Abdulganiyu, A. (2025). Access to and Utilization of Dental Care Services by Older Adults in Nigeria: Barriers and Facilitators. Special Care in Dentistry, 45(3), e70040. https://doi.org/10.1111/scd.70040

Gaurav, A., Bakht, P., Saini, M., Pandey, S., & Pathania, R. (2023). Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors. Microbiology, 169(5), 001333. https://doi.org/10.1099/mic.0.001333

Green, A. J., Mohlenkamp, M. J., Das, J., Chaudhari, M., Truong, L., Tanguay, R. L., & Reif, D. M. (2021). Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology. PLoS Computational Biology, 17(7), e1009135. https://doi.org/10.1371/journal.pcbi.1009135

Hassibian, S., Amin, M., Taghdisi, S. M., Sameiyan, E., Ghaffari, R., Alibolandi, M., Ramezani, M., Abnous, K., & Dehnavi, S. M. (2025). Aptamers: Design, Theory, and Applications to Diagnosis and Therapy for Diseases. MedComm, 6(5), e70180. https://doi.org/10.1002/mco2.70180

Helmy, Y. A., Taha-Abdelaziz, K., Hawwas, H. A. E.-H., Ghosh, S., AlKafaas, S. S., Moawad, M. M. M., Saied, E. M., Kassem, I. I., & Mawad, A. M. M. (2023). Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens. Antibiotics, 12(2), Article 2. https://doi.org/10.3390/antibiotics12020274

Hughes, D., & Karlén, A. (2014). Discovery and preclinical development of new antibiotics. Upsala Journal of Medical Sciences, 119(2), Article 2. https://doi.org/10.3109/03009734.2014.896437

Hussien, A., Musa, A., Nour El-Din, H. T., Helal, A. M., Nagy, Y. I., Ezzat, H. G., Attia, A. S., Mayhoub, A. S., Shalaby, K., Parambi, D. G. T., & Elsebaie, M. M. (n.d.). Phenyltriazole-based sulfonamides: Novel dual-target agents against MRSA biofilms and resistant pathogens. RSC Advances, 15(22), 17186–17202. https://doi.org/10.1039/d5ra02412a

Juszczuk-Kubiak, E. (2024). Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based on Quorum Sensing (QS) Signal-Response System and Innovative Non-Antibiotic Strategies for Their Elimination. International Journal of Molecular Sciences, 25(5), Article 5. https://doi.org/10.3390/ijms25052655

Konaklieva, M. I., & Plotkin, B. J. (2023). Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery. Antibiotics, 12(2), Article 2. https://doi.org/10.3390/antibiotics12020315

Kumar, V., Yasmeen, N., Pandey, A., Ahmad Chaudhary, A., Alawam, A. S., Ahmad Rudayni, H., Islam, A., Lakhawat, S. S., Sharma, P. K., & Shahid, M. (2023). Antibiotic adjuvants: Synergistic tool to combat multi-drug resistant pathogens. Frontiers in Cellular and Infection Microbiology, 13, 1293633. https://doi.org/10.3389/fcimb.2023.1293633

Lawal, O., Elechi, K., Adekunle, F., Farinde, O., Kolapo, T., Igbokwe, C., Elechi, U., Victoria, & Chikezie, O. (2025). A Review on Artificial Intelligence and Point-of-Care Diagnostics to Combat Antimicrobial Resistance in Resource-Limited Healthcare Settings like Nigeria: Review Article. Journal of Pharma Insights and Research, 3(2), Article 2. https://doi.org/10.69613/reeh4906

Lawal, O. P., Adedayo, O. A., Dorcas, S. I., Akanbi, O. O., Okafor, B. C., Kanu, I., Sone, P. E., Patrick, J. O., Fabiyi, T. O., Adeyemi, B. I., Oziegbe, E. E., & Busari, A. M. (2025). Biomarkers for Tuberculosis Diagnosis and Monitoring: A Review of Translational Progress. Asian Journal of Microbiology and Biotechnology, 10(1), 115–130. https://doi.org/10.56557/ajmab/2025/v10i19351

Lawal, O. P., Adekunle, J. F., Abiodun, A. V., Orobator, E. T., Agbo, O. S., Ugoagwu, K. U., Akintayo, E. A., Olaniyi, A. O., Otabil, C., Mandal, M., & Elechi, K. W. (2025). Modulating Gut Microbiota for Precision Medicine in Diabetes: A Paradigm Shift in Personalized Treatment Strategies. Asian Journal of Research and Reports in Endocrinology, 8(1), 94–109. https://doi.org/10.9734/ajrre/2025/v8i1110

Lawal, O. P., Ahmed, N. K., Ilesanmi, T. A., Anthony, G. I., Nwosu, S. N., Ogungbemiro, F. O., Olaide, Z., Adeniyi, M. M., Okoye, U. L., Olufunmilayo, A. M., Christopher, A. A., & Oseghale, I. D. (2024). The Impact of Antimicrobial Resistance on Cancer Treatment: A Systematic Review of Current Evidence and Future Directions. Asian Journal of Research in Medical and Pharmaceutical Sciences, 13(4), 9–27. https://doi.org/10.9734/ajrimps/2024/v13i4270

Lawal, O. P., Ayomide, I. T., Kwame, A. B., Christopher, A. A., Ogochukwu, D. J., Okoye, C. A., Temitope, A. O., Obasi, D. E., Bemigho, A. P., Andrew, I. A., Obi, C. N., Zainab, O., & Eseohe, E. G. (2024). Prevalence of Extended-Spectrum- Beta-Lactamase-Producing Bacterial Species Isolated from Handbags of Women in Abeokuta, Nigeria. South Asian Journal of Research in Microbiology, 18(11), 12–24. https://doi.org/10.9734/sajrm/2024/v18i11396

Lawal, O. P., Egwuatu, E. C., Akanbi, K. O., Orobator, E. T., Eweje, O. Z., Omotayo, E. O., Igbokwe, C., Ogundeko-Olugbami, O., Awuah, S. B., Chibueze, E. S., Lawal, O. P., Egwuatu, E. C., Akanbi, K. O., Orobator, E. T., Eweje, O. Z., Omotayo, E. O., Igbokwe, C., Ogundeko-Olugbami, O., Awuah, S. B., & Chibueze, E. S. (2025). Fighting Resistance With Data: Leveraging Digital Surveillance to Address Antibiotic Misuse in Nigeria. Path of Science, 11(3), Article 3. https://doi.org/10.22178/pos.115-25

Le Terrier, C., Mlynarcik, P., Sadek, M., Nordmann, P., & Poirel, L. (n.d.). Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases. Antimicrobial Agents and Chemotherapy, 68(11), e00775-24. https://doi.org/10.1128/aac.00775-24

Li, Q.-J., Xing, F., Wu, W.-T., Zhe, M., Zhang, W.-Q., Qin, L., Huang, L.-P., Zhao, L.-M., Wang, R., Fan, M.-H., Zou, C.-Y., Duan, W.-Q., Li-Ling, J., & Xie, H.-Q. (2025). Multifunctional metal–organic frameworks as promising nanomaterials for antimicrobial strategies. Burns & Trauma, 13, tkaf008. https://doi.org/10.1093/burnst/tkaf008

Mayorga-Ramos, A., Zúñiga-Miranda, J., Carrera-Pacheco, S. E., Barba-Ostria, C., & Guamán, L. P. (2023). CRISPR-Cas-Based Antimicrobials: Design, Challenges, and Bacterial Mechanisms of Resistance. ACS Infectious Diseases, 9(7), 1283–1302. https://doi.org/10.1021/acsinfecdis.2c00649

Méndez-Samperio, P. (2014). Peptidomimetics as a new generation of antimicrobial agents: Current progress. Infection and Drug Resistance, 7, 229–237. https://doi.org/10.2147/IDR.S49229

Morgan, J. M., Lam, H. N., Delgado, J., Luu, J., Mohammadi, S., Isberg, R. R., Wang, H., & Auerbuch, V. (2018). An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia. Frontiers in Cellular and Infection Microbiology, 8. https://doi.org/10.3389/fcimb.2018.00404

Murugaiyan, J., Kumar, P. A., Rao, G. S., Iskandar, K., Hawser, S., Hays, J. P., Mohsen, Y., Adukkadukkam, S., Awuah, W. A., Jose, R. A. M., Sylvia, N., Nansubuga, E. P., Tilocca, B., Roncada, P., Roson-Calero, N., Moreno-Morales, J., Amin, R., Kumar, B. K., Kumar, A., … Dongen, M. B. M. van. (2022). Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics. Antibiotics, 11(2), 200. https://doi.org/10.3390/antibiotics11020200

Muteeb, G., Rehman, M. T., Shahwan, M., & Aatif, M. (2023). Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review. Pharmaceuticals, 16(11), 1615. https://doi.org/10.3390/ph16111615

Mwangi, J., Kamau, P. M., Thuku, R. C., & Lai, R. (2023). Design methods for antimicrobial peptides with improved performance. Zoological Research, 44(6), 1095–1114. https://doi.org/10.24272/j.issn.2095-8137.2023.246

Negash, K. H., Norris, J. K. S., & Hodgkinson, J. T. (2019). Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs? Molecules, 24(18), Article 18. https://doi.org/10.3390/molecules24183314

Okafor, C. E., Egwuatu, E. C., Owosagba, V. A., Njei, T., Adeyemi, B. I., Onuche, P. U. O., Adams, A., Ugwuja, C. B., Chibueze, E. S., & Lawal, O. P. (2025). From Bench to Bedside: Medicinal Chemistry Strategies in the Development of Kinase Inhibitors for Cancer Therapy. Journal of Cancer and Tumor International, 15(2), 79–96. https://doi.org/10.9734/jcti/2025/v15i2294

Olsen, N. S., & Riber, L. (2025). Metagenomics as a Transformative Tool for Antibiotic Resistance Surveillance: Highlighting the Impact of Mobile Genetic Elements with a Focus on the Complex Role of Phages. Antibiotics, 14(3), 296. https://doi.org/10.3390/antibiotics14030296

Onwuemelem, L. A., Orobator, E. T., Onyedum, N. N., Chibueze, E. S., Kanu, I., Christopher, A. A., Lawal, O., & Ben-Anioke, B. (2025). Molecular Mechanisms of Clonal Hematopoiesis in Age-Related Cardiovascular Disease and Hematologic Malignancies: Review Article. Journal of Pharma Insights and Research, 3(2), Article 2. https://doi.org/10.69613/gexxbw35

Oseghale, I. D., Lawal, O. P., Ubebe, D. O., Orjiewulu, V. C., Igunma, A. A., Odey, O. P., Ajibola, D. T., Chima, D. I., Tuador, N. K., & Ani, C. P. (2024). Ethnomedicinal and Phytopharmacological Aspects of Vernonia amygdalina (Bitter Leaf) Utilized as a Traditional Medicinal Herb. Asian Journal of Research in Biochemistry, 14(6), Article 6. https://doi.org/10.9734/ajrb/2024/v14i6326

Parvin, N., Joo, S. W., & Mandal, T. K. (2025). Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications. Antibiotics, 14(2), 207. https://doi.org/10.3390/antibiotics14020207

Peterson, A. A., & Liu, D. R. (2023). Small-molecule discovery through DNA-encoded libraries. Nature Reviews. Drug Discovery, 22(9), 699–722. https://doi.org/10.1038/s41573-023-00713-6

Sarabando, S. N., Palmeira, A., Sousa, M. E., Faustino, M. A. F., & Monteiro, C. J. P. (2023). Photomodulation Approaches to Overcome Antimicrobial Resistance. Pharmaceuticals, 16(5), 682. https://doi.org/10.3390/ph16050682

Sharma, B., Shukla, S., Rattan, R., Fatima, M., Goel, M., Bhat, M., Dutta, S., Ranjan, R. K., & Sharma, M. (2022). Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects. International Journal of Biomaterials, 2022, 6819080. https://doi.org/10.1155/2022/6819080

Si, Z., Pethe, K., & Chan-Park, M. B. (2023). Chemical Basis of Combination Therapy to Combat Antibiotic Resistance. JACS Au, 3(2), 276–292. https://doi.org/10.1021/jacsau.2c00532

Skwarczynski, M., Bashiri, S., Yuan, Y., Ziora, Z. M., Nabil, O., Masuda, K., Khongkow, M., Rimsueb, N., Cabral, H., Ruktanonchai, U., Blaskovich, M. A. T., & Toth, I. (2022). Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents. Antibiotics, 11(3), 412. https://doi.org/10.3390/antibiotics11030412

Sully, E. K., Malachowa, N., Elmore, B. O., Alexander, S. M., Femling, J. K., Gray, B. M., DeLeo, F. R., Otto, M., Cheung, A. L., Edwards, B. S., Sklar, L. A., Horswill, A. R., Hall, P. R., & Gresham, H. D. (2014). Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance. PLoS Pathogens, 10(6), e1004174. https://doi.org/10.1371/journal.ppat.1004174

Teixeira, M. C., Carbone, C., Sousa, M. C., Espina, M., Garcia, M. L., Sanchez-Lopez, E., & Souto, E. B. (2020). Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs). Nanomaterials, 10(3), 560. https://doi.org/10.3390/nano10030560

Usman, M., Tang, J.-W., Li, F., Lai, J.-X., Liu, Q.-H., Liu, W., & Wang, L. (2022). Recent advances in surface enhanced Raman spectroscopy for bacterial pathogen identifications. Journal of Advanced Research, 51, 91–107. https://doi.org/10.1016/j.jare.2022.11.010

Vivekanandan, K. E., Kumar, P. V., Jaysree, R. C., & Rajeshwari, T. (2025). Exploring molecular mechanisms of drug resistance in bacteria and progressions in CRISPR/Cas9-based genome expurgation solutions. Global Medical Genetics, 12(2), 100042. https://doi.org/10.1016/j.gmg.2025.100042

Wang, C., Xu, P., Li, X., Zheng, Y., & Song, Z. (2022). Research progress of stimulus-responsive antibacterial materials for bone infection. Frontiers in Bioengineering and Biotechnology, 10, 1069932. https://doi.org/10.3389/fbioe.2022.1069932

Wang, D., Yin, F., Li, Z., Zhang, Y., & Shi, C. (2025). Current progress and remaining challenges of peptide–drug conjugates (PDCs): Next generation of antibody-drug conjugates (ADCs)? Journal of Nanobiotechnology, 23, 305. https://doi.org/10.1186/s12951-025-03277-2

Wu, L., Wen, Y., Leng, D., Zhang, Q., Dai, C., Wang, Z., Liu, Z., Yan, B., Zhang, Y., Wang, J., He, S., & Bo, X. (2021). Machine learning methods, databases and tools for drug combination prediction. Briefings in Bioinformatics, 23(1), bbab355. https://doi.org/10.1093/bib/bbab355

Yamin, D., Uskoković, V., Wakil, A. M., Goni, M. D., Shamsuddin, S. H., Mustafa, F. H., Alfouzan, W. A., Alissa, M., Alshengeti, A., Almaghrabi, R. H., Fares, M. A. A., Garout, M., Kaabi, N. A. A., Alshehri, A. A., Ali, H. M., Rabaan, A. A., Aldubisi, F. A., Yean, C. Y., & Yusof, N. Y. (2023). Current and Future Technologies for the Detection of Antibiotic-Resistant Bacteria. Diagnostics, 13(20), 3246. https://doi.org/10.3390/diagnostics13203246

Zeng, L., Gupta, P., Chen, Y., Wang, E., Ji, L., Chao, H., & Chen, Z.-S. (2017). The development of anticancer ruthenium(II) complexes: From single molecule compounds to nanomaterials. Chemical Society Reviews, 46(19), 5771–5804. https://doi.org/10.1039/c7cs00195a

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