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Review Article

Young Hearts, Troubled Minds: The Two-Way Link Between Mental Illness and High Blood Pressure Worldwide

Authors

  • Enibokun Theresa Orobator College of Medicine and Veterinary Medicine, University of Edinburgh, UK https://orcid.org/0009-0002-7426-1935

    theresaorobator@gmail.com

  • Wonderful Oluwatoyin Anosike Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, UK https://orcid.org/0009-0008-8587-3156
  • Opeyemi Zainab Malah Lagos State University Teaching Hospital, Lagos, Nigeria
  • Negasi Tsegay Mississippi State Department of Health, Ryan White Part B, Jackson, MS, USA
  • Abdulkareem Misbahudeen Olohuntoyin Kwara State University Teaching Hospital, Ilorin, Nigeria https://orcid.org/0009-0003-2045-4093
  • Precious Esong Sone College of Business, East Carolina University, USA
  • Adeniyi Adewole Aniyeloye Lagos University Teaching Hospital, Lagos, Nigeria

Abstract

Hypertension and common mental disorders crest on the same timeline, from late teens into early midlife, yet healthcare pathways rarely intersect. This review asks two questions: How strongly do mood, anxiety, trauma-related, or severe mental illnesses alter blood-pressure trajectories, and when does elevated pressure echo back on mental health? We searched the biomedical and grey literature (2000-2025) for studies involving 15- to 45-year-olds and distilled converging themes from epidemiology, genetics, mechanistic work, and intervention trials. Consistent evidence shows depressive, anxious, and trauma-related conditions tilt autonomic and inflammatory set points long before a hypertension diagnosis is made. The reverse pathway proves selective: pressure-driven vascular injury, medication effects, and disease labeling nurture later mood disturbance, but early-stage hypertension is often affectively silent. Importantly, collaborative-care models, whether nurse-led in community clinics or delivered through text and app platforms, repeatedly produce parallel gains in mood scores and systolic control. Joint screening and integrated management in young adults, therefore, offer a practical lever to blunt two interwoven epidemics.

Keywords:

Bidirectional Pathways Collaborative Care Hypertension Mental Health Disorders Young Adults

Article information

Journal

Journal of Medical Science, Biology, and Chemistry

Volume (Issue)

2(2), (2025)

Pages

1-14

Published

03-07-2025

How to Cite

Orobator, E. T., Anosike, W. O., Malah, O. Z., Tsegay, N., Olohuntoyin, A. M., Sone, P. E., & Aniyeloye, A. A. (2025). Young Hearts, Troubled Minds: The Two-Way Link Between Mental Illness and High Blood Pressure Worldwide. Journal of Medical Science, Biology, and Chemistry, 2(2), 1-14. https://doi.org/10.69739/jmsbc.v2i2.693

References

Ali, M. K., Chwastiak, L., Poongothai, S., Emmert-Fees, K. M., Patel, S. A., Anjana, R. M., ... & INDEPENDENT Study Group. (2020). Effect of a collaborative care model on depressive symptoms and glycated hemoglobin, blood pressure, and serum cholesterol among patients with depression and diabetes in India: the INDEPENDENT randomized clinical trial. Jama, 324(7), 651-662. https://doi.org/10.1001/jama.2020.11747

Al-shoaibi, A. A. A., Lee, C. M., Raney, J. H., Ganson, K. T., Testa, A., Dooley, E. E., Gooding, H. C., Gabriel, K. P., Baker, F. C., & Nagata, J. M. (2024). Associations of adverse childhood experiences with blood pressure among early adolescents in the United States. American Journal of Preventive Cardiology, 20, 100883. https://doi.org/10.1016/j.ajpc.2024.100883

Alvarez, C., Perrin, N., Carson, K. A., Marsteller, J. A., & Cooper, L. A. (2022). Adverse Childhood Experiences, Depression, Patient Activation, and Medication Adherence Among Patients With Uncontrolled Hypertension. American Journal of Hypertension, 36(4), 209–216. https://doi.org/10.1093/ajh/hpac123

American Heart Association. (2023, November 6). Depression, anxiety and stress linked to poor heart health in two new studies. American Heart Association. https://newsroom.heart.org/news/depression-anxiety-and-stress-linked-to-poor-heart-health-in-two-new-studies

Andrade, C. (2021). β-Blockers and the Risk of New-Onset Depression: Meta-analysis Reassures, but the Jury Is Still Out. The Journal of Clinical Psychiatry, 82(3), 21f14095. https://doi.org/10.4088/JCP.21f14095

Annesi, J. J. (2022). Effects of Behaviorally Supported Exercise and Exercise-Induced Mood Changes on Elevated Blood Pressure and Hypertension in African American Adults with Severe Obesity. Journal of Immigrant and Minority Health, 24(3), 721–729. https://doi.org/10.1007/s10903-021-01220-9

Armstrong, M., Kerndt, C. C., & Moore, R. A. (2025). Physiology, Baroreceptors. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK538172

Astudillo, Y., Kibrom, S., Pereira, T., Solomon, S., Krishnan, S., & Samsonov, D. (2024). Association between anxiety and elevated blood pressure in adolescent patients: A single-center cross-sectional study. Journal of Hypertension, 42(4), 644–649. https://doi.org/10.1097/HJH.0000000000003652

Biaggioni, I., Shibao, C. A., Diedrich, A., Muldowney, J. A. S., Laffer, C. L., & Jordan, J. (2019). Blood Pressure Management in Afferent Baroreflex Failure: JACC Review Topic of the Week. Journal of the American College of Cardiology, 74(23), 2939–2947. https://doi.org/10.1016/j.jacc.2019.10.027

Bogner, H. R., & de Vries, H. F. (2008). Integration of Depression and Hypertension Treatment: A Pilot, Randomized Controlled Trial. Annals of Family Medicine, 6(4), 295–301. https://doi.org/10.1370/afm.843

Cai, L., Liu, Y., & He, L. (2022). Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being. General Psychiatry, 35(5), e100877. https://doi.org/10.1136/gpsych-2022-100877

Caropreso, L., de Azevedo Cardoso, T., Eltayebani, M., & Frey, B. N. (2020). Preeclampsia as a risk factor for postpartum depression and psychosis: A systematic review and meta-analysis. Archives of Women’s Mental Health, 23(4), 493–505. https://doi.org/10.1007/s00737-019-01010-1

CDC. (2025, January 28). High Blood Pressure Facts. High Blood Pressure. https://www.cdc.gov/high-blood-pressure/data-research/facts-stats/index.html

CDC National Center for Health Statistics. (2024, November 5). Hypertension Prevalence, Awareness, Treatment, and Control Among Adults Age 18 and Older: United States, August 2021–August 2023. https://doi.org/10.15620/cdc/164016

Centers for Medicare & Medicaid Services. (2023). Frequently Asked Questions about Billing Medicare for Behavioral Health Integration (BHI) Services.

Chan, J. K. N., Correll, C. U., Wong, C. S. M., Chu, R. S. T., Fung, V. S. C., Wong, G. H. S., Lei, J. H. C., & Chang, W. C. (2023). Life expectancy and years of potential life lost in people with mental disorders: A systematic review and meta-analysis. eClinicalMedicine, 65, 102294. https://doi.org/10.1016/j.eclinm.2023.102294

Chang, S.-C., Goh, K. K., & Lu, M.-L. (2021). Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia: State-of-the-art and future perspectives. World Journal of Psychiatry, 11(10), 696–710. https://doi.org/10.5498/wjp.v11.i10.696

Chen, S., Conwell, Y., Xue, J., Li, L. W., Tang, W., Bogner, H. R., & Dong, H. (2018). Protocol of an ongoing randomized controlled trial of care management for comorbid depression and hypertension: The Chinese Older Adult Collaborations in Health (COACH) study. BMC Geriatrics, 18(1), 124. https://doi.org/10.1186/s12877-018-0808-1

Chen, S., Conwell, Y., Xue, J., Li, L., Zhao, T., Tang, W., Bogner, H., & Dong, H. (2022). Effectiveness of integrated care for older adults with depression and hypertension in rural China: A cluster randomized controlled trial. PLOS Medicine, 19(10), e1004019. https://doi.org/10.1371/journal.pmed.1004019

Cleveland Clinic. (n.d.). HPA Axis: The Stress Response System. Cleveland Clinic. Retrieved May 21, 2025, from https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis

Dayabandara, M., Hanwella, R., Ratnatunga, S., Seneviratne, S., Suraweera, C., & de Silva, V. A. (2017). Antipsychotic-associated weight gain: Management strategies and impact on treatment adherence. Neuropsychiatric Disease and Treatment, 13, 2231–2241. https://doi.org/10.2147/NDT.S113099

De Hert, M., Schreurs, V., Vancampfort, D., & Van Winkel, R. (2009). Metabolic syndrome in people with schizophrenia: A review. World Psychiatry, 8(1), 15–22. https://doi.org/10.1002/j.2051-5545.2009.tb00199.x

Dolezsar, C. M., McGrath, J. J., Herzig, A. J. M., & Miller, S. B. (2014a). Perceived Racial Discrimination and Hypertension: A Comprehensive Systematic Review. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 33(1), 20–34. https://doi.org/10.1037/a0033718

Dolezsar, C. M., McGrath, J. J., Herzig, A. J. M., & Miller, S. B. (2014b). Perceived Racial Discrimination and Hypertension: A Comprehensive Systematic Review. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 33(1), 20–34. https://doi.org/10.1037/a0033718

Fan, Y., Fan, A., Yang, Z., & Fan, D. (2025). Global burden of mental disorders in 204 countries and territories, 1990–2021: Results from the global burden of disease study 2021. BMC Psychiatry, 25, 486. https://doi.org/10.1186/s12888-025-06932-y

Fontes, M. A. P., Marins, F. R., Patel, T. A., de Paula, C. A., dos Santos Machado, L. R., de Sousa Lima, É. B., Ventris-Godoy, A. C., Viana, A. C. R., Linhares, I. C. S., Xavier, C. H., Filosa, J. A., & Patel, K. P. (2023). Neurogenic Background for Emotional Stress-Associated Hypertension. Current Hypertension Reports, 25(7), 107–116. https://doi.org/10.1007/s11906-023-01235-7

Greaney, J. L., Darling, A. M., Saunders, E. F. H., & Almeida, D. M. (2023). Daily Stress and Microvascular Dysfunction: The Buffering Effect of Physical Activity. Exercise and Sport Sciences Reviews, 51(1), 19–26. https://doi.org/10.1249/JES.0000000000000310

Hainsworth, A. H., Markus, H. S., & Schneider, J. A. (2024). Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. Hypertension, 81(1), 75–86. https://doi.org/10.1161/HYPERTENSIONAHA.123.19943

Hart, E. C., Charkoudian, N., Wallin, B. G., Curry, T. B., Eisenach, J. H., & Joyner, M. J. (2009). Sex Differences in Sympathetic Neural-Hemodynamic Balance. Hypertension, 53(3), 27-36. https://doi.org/10.1161/HYPERTENSIONAHA.108.126391

Hassan, S., Liu, S., Johnson, L. C. M., Patel, S. A., Emmert-Fees, K. M. F., Suvada, K., Tandon, N., Sridhar, G. R., Aravind, S., Poongothai, S., Anjana, R. M., Mohan, V., Chwastiak, L., & Ali, M. K. (2024). Association of collaborative care intervention features with depression and metabolic outcomes in the INDEPENDENT study: A mixed methods study. Primary Care Diabetes, 18(3), 319–326. https://doi.org/10.1016/j.pcd.2024.02.001

Hill, W. D., Weiss, A., Liewald, D. C., Davies, G., Porteous, D. J., Hayward, C., McIntosh, A. M., Gale, C. R., & Deary, I. J. (2020). Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life. Molecular Psychiatry, 25(11), 3034–3052. https://doi.org/10.1038/s41380-019-0387-3

Hodes, G. E., Ménard, C., & Russo, S. J. (2016). Integrating Interleukin-6 into depression diagnosis and treatment. Neurobiology of Stress, 4, 15–22. https://doi.org/10.1016/j.ynstr.2016.03.003

Howard, G., Prineas, R., Moy, C., Cushman, M., Kellum, M., Temple, E., Graham, A., & Howard, V. (2006). Racial and Geographic Differences in Awareness, Treatment, and Control of Hypertension: The REasons for Geographic And Racial Differences in Stroke Study. Stroke, 37(5), 1171–1178. https://doi.org/10.1161/01.STR.0000217222.09978.ce

IHME. (n.d.). Mental health. IHME. Retrieved May 21, 2025, from https://www.healthdata.org/research-analysis/health-risks-issues/mental-health

Javaheri, S., Storfer-Isser, A., Rosen, C. L., & Redline, S. (2008). Sleep Quality and Elevated Blood Pressure in Adolescents. Circulation, 118(10), 1034–1040. https://doi.org/10.1161/CIRCULATIONAHA.108.766410

Jeon, S. W., Chang, Y., Lim, S.-W., Cho, J., Kim, H.-N., Kim, K.-B., Kim, J., Kim, Y. H., Shin, D.-W., Oh, K.-S., Shin, Y.-C., & Ryu, S. (2020). Bidirectional association between blood pressure and depressive symptoms in young and middle-age adults: A cohort study. Epidemiology and Psychiatric Sciences, 29, e142. https://doi.org/10.1017/S2045796020000542

Joyner, M. J., Barnes, J. N., Hart, E. C., Wallin, B. G., & Charkoudian, N. (2015). Neural Control of the Circulation: How Sex and Age Differences Interact in Humans. Comprehensive Physiology, 5(1), 193–215. https://doi.org/10.1002/cphy.c140005

Kandasamy, G., Subramani, T., Almanasef, M., Orayj, K., Shorog, E., Alshahrani, A. M., Alsaab, A., Alshahrani, Z. M., & Palayakkodan, S. (2025). Mental health and hypertension: Assessing the prevalence of anxiety and depression and their associated factors in a tertiary care population. Frontiers in Public Health, 13, 1545386. https://doi.org/10.3389/fpubh.2025.1545386

Katon, W. J., Lin, E. H. B., Von, K. M., Ciechanowski, P., Ludman, E. J., Young, B., Peterson, D., Rutter, C. M., McGregor, M., & McCulloch, D. (2010). Collaborative Care for Patients with Depression and Chronic Illnesses. New England Journal of Medicine, 363(27), 2611–2620. https://doi.org/10.1056/NEJMoa1003955

Katon, W., Russo, J., Lin, E. H. B., Schmittdiel, J., Ciechanowski, P., Ludman, E., Peterson, D., Young, B., & Von Korff, M. (2012). Cost-effectiveness of a Multicondition Collaborative Care Intervention: A Randomized Controlled Trial. Archives of General Psychiatry, 69(5), 506–514. https://doi.org/10.1001/archgenpsychiatry.2011.1548

Keller, J., Gomez, R., Williams, G., Lembke, A., Lazzeroni, L., Murphy, G. M., & Schatzberg, A. F. (2017). HPA Axis in Major Depression: Cortisol, Clinical Symptomatology, and Genetic Variation Predict Cognition. Molecular Psychiatry, 22(4), 527–536. https://doi.org/10.1038/mp.2016.120

Khandaker, G. M., Pearson, R. M., Zammit, S., Lewis, G., & Jones, P. B. (2014). Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: A population-based longitudinal study. JAMA Psychiatry, 71(10), 1121–1128. https://doi.org/10.1001/jamapsychiatry.2014.1332

Kieling, C., Buchweitz, C., Caye, A., Silvani, J., Ameis, S. H., Brunoni, A. R., ... & Szatmari, P. (2024). Worldwide prevalence and disability from mental disorders across childhood and adolescence: evidence from the global burden of disease study. JAMA Psychiatry, 81(4), 347–356. https://doi.org/10.1001/jamapsychiatry.2023.5051

Ko, D. T., Hebert, P. R., Coffey, C. S., Sedrakyan, A., Curtis, J. P., & Krumholz, H. M. (2002). Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA, 288(3), 351–357. https://doi.org/10.1001/jama.288.3.351

Kogon, A. J., Maqsood, A. M., LoGuidice, J., Amaral, S., Meyers, K., & Mitchell, J. A. (2024). Sleep Duration and Blood Pressure in Youth Referred for Elevated Blood Pressure Evaluation. Pediatrics, 154(1), e2023062940. https://doi.org/10.1542/peds.2023-062940

Kougias, P., Weakley, S. M., Yao, Q., Lin, P. H., & Chen, C. (2010). Arterial baroreceptors in the management of systemic hypertension. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 16(1), RA1–RA8.

Krantz, D. S., Gabbay, F. H., Belleau, E. A., Aliaga, P. A., Wynn, G. H., Stein, M. B., Ursano, R. J., & Naifeh, J. A. (2024). PTSD, Comorbidities, Gender, and Increased Risk of Cardiovascular Disease in a Large Military Cohort. medRxiv, 2024.04.13.24305769. https://doi.org/10.1101/2024.04.13.24305769

Landsbergis, P. A., Dobson, M., Koutsouras, G., & Schnall, P. (2013). Job Strain and Ambulatory Blood Pressure: A Meta-Analysis and Systematic Review. American Journal of Public Health, 103(3), e61–e71. https://doi.org/10.2105/AJPH.2012.301153

Levin, J. B., Moore, D. J., Depp, C., Montoya, J. L., Briggs, F., Rahman, M., Stange, K. C., Einstadter, D., Weise, C., Conroy, C., Yala, J., Radatz, E., & Sajatovic, M. (2022). Using mHealth to improve adherence and reduce blood pressure in individuals with hypertension and bipolar disorder (iTAB-CV): Study protocol for a 2-stage randomized clinical trial. Trials, 23, 539. https://doi.org/10.1186/s13063-022-06449-9

Libowitz, M. R., & Nurmi, E. L. (2021). The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome in Children. Frontiers in Psychiatry, 12, 623681. https://doi.org/10.3389/fpsyt.2021.623681

Lim, L. F., Solmi, M., & Cortese, S. (2021). Association between anxiety and hypertension in adults: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 131, 96-119. https://doi.org/10.1016/j.neubiorev.2021.08.031

Lim, Y., Kim, B. C., Yoon, S. S., Kim, H. J., Lee, S. J., Lee, M. H., Kim, J. H., Park, S. J., Jeong, S., & Han, H. W. (2023). Inverse association between changes in systolic and diastolic blood pressure and risk of depression: A nationally representative cohort study. Journal of Affective Disorders, 335, 49–56. https://doi.org/10.1016/j.jad.2023.04.107

Liu, X., Matthews, T. A., Chen, L., & Li, J. (2022a). The associations of job strain and leisure-time physical activity with the risk of hypertension: The population-based Midlife in the United States cohort study. Epidemiology and Health, 44, e2022073. https://doi.org/10.4178/epih.e2022073

Liu, X., Matthews, T. A., Chen, L., & Li, J. (2022b). The associations of job strain and leisure-time physical activity with the risk of hypertension: The population-based Midlife in the United States cohort study. Epidemiology and Health, 44, e2022073. https://doi.org/10.4178/epih.e2022073

Mai, A. S., Lim, O. Z. H., Ho, Y. J., Kong, G., Lim, G. E. H., Ng, C. H., Ho, C., Ho, R., Lim, Y., Kuntjoro, I., Tay, E., Yip, J., Chew, N. W. S., & Low, T.-T. (2022). Prevalence, Risk Factors and Intervention for Depression and Anxiety in Pulmonary Hypertension: A Systematic Review and Meta-analysis. Frontiers in Medicine, 9, 765461. https://doi.org/10.3389/fmed.2022.765461

Markovitz, J. H., Matthews, K. A., Whooley, M., Lewis, C. E., & Greenlund, K. J. (2004). Increases in job strain are associated with incident hypertension in the CARDIA Study. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine, 28(1), 4–9. https://doi.org/10.1207/s15324796abm2801_2

Mbarak, B., Kilewo, C., Kuganda, S., & Sunguya, B. F. (2019). Postpartum depression among women with pre-eclampsia and eclampsia in Tanzania; a call for integrative intervention. BMC Pregnancy and Childbirth, 19(1), 270. https://doi.org/10.1186/s12884-019-2395-3

McGregor, M., Lin, E. H. B., & Katon, W. J. (2011). TEAMcare. The Journal of Ambulatory Care Management, 34(2), 152–162. https://doi.org/10.1097/JAC.0b013e31820ef6a4

Mills, K. T., Stefanescu, A., & He, J. (2020). The global epidemiology of hypertension. Nature Reviews. Nephrology, 16(4), 223–237. https://doi.org/10.1038/s41581-019-0244-2

Ngo, V. K., Vu, T. T., Vu, Q. A., McBain, R., Yu, G., Nguyen, N. B., Mai Thi Nguyen, H., Ho, H. T., & Van Hoang, M. (2023). Study protocol for type II hybrid implementation-effectiveness trial of strategies for depression care task-sharing in community health stations in Vietnam: DEP Project. BMC Public Health, 23(1), 1450. https://doi.org/10.1186/s12889-023-16312-4

Niknam, M., Zolfagharypoor, A., Cheraghi, L., Izadi, N., Azizi, F., & Amiri, P. (2024). Blood pressure status, quality of life, and emotional states in adults with different disease awareness and treatment adherence. Scientific Reports, 14(1), 26699. https://doi.org/10.1038/s41598-024-77857-x

Obas, K. A., Kwiatkowski, M., Bytyci-Katanolli, A., Statovci, S., Jerliu, N., Ramadani, Q., Fota, N., Gerold, J., Zahorka, M., & Probst-Hensch, N. (2023). Prospective association between depressive symptoms and blood-pressure related outcomes in Kosovo. PLOS Global Public Health, 3(4), e0000851. https://doi.org/10.1371/journal.pgph.0000851

Ofori, M. A., Mensah, D. K., Nizeyimana, I., Jha, N., Zeba, Z., & Roy, S. (2024). High Blood Pressure and Depression Among the Working Population of Ghana: A Generalized Linear Model of the Risk Factors. Depression and Anxiety, 2024, 5261760. https://doi.org/10.1155/2024/5261760

PAHO/WHO. (2020). HEARTS in the Americas: Technical Package - PAHO/WHO. Pan American Health Organization. https://www.paho.org/en/hearts-americas/hearts-americas-technical-package

Parker, E. D., Schmitz, K. H., Jacobs, D. R., Dengel, D. R., & Schreiner, P. J. (2007). Physical Activity in Young Adults and Incident Hypertension Over 15 Years of Follow-Up: The CARDIA Study. American Journal of Public Health, 97(4), 703–709. https://doi.org/10.2105/AJPH.2004.055889

Pathways Linking Post-Traumatic Stress Disorder to Incident Ischemic Heart Disease in Women: Call to Action. (2024). JACC: Advances, 3(1), 100744. https://doi.org/10.1016/j.jacadv.2023.100744

Piette, J. D., Datwani, H., Gaudioso, S., Foster, S. M., Westphal, J., Perry, W., Rodríguez-Saldaña, J., Mendoza-Avelares, M. O., & Marinec, N. (2012). Hypertension management using mobile technology and home blood pressure monitoring: Results of a randomized trial in two low/middle-income countries. Telemedicine Journal and E-Health: The Official Journal of the American Telemedicine Association, 18(8), 613–620. https://doi.org/10.1089/tmj.2011.0271

Poppy Koronka, Health Correspondent. (2025, May 20). Teen health at ‘tipping point’ as obesity and mental illness soar. https://www.thetimes.com/uk/healthcare/article/teen-health-tipping-point-obesity-mental-illness-soar-nz2fsd2t0

Qi, H., Wen, F.-Y., Xie, Y.-Y., Liu, X.-H., Li, B.-X., Peng, W.-J., Cao, H., & Zhang, L. (2023). Associations between depressive, anxiety, stress symptoms and elevated blood pressure: Findings from the CHCN-BTH cohort study and a two-sample Mendelian randomization analysis. Journal of Affective Disorders, 341, 176–184. https://doi.org/10.1016/j.jad.2023.08.086

Qiu, T., Jiang, Z., Chen, X., Dai, Y., & Zhao, H. (2023). Comorbidity of Anxiety and Hypertension: Common Risk Factors and Potential Mechanisms. International Journal of Hypertension, 2023, 9619388. https://doi.org/10.1155/2023/9619388

Reis, D. J., Kaizer, A. M., Kinney, A. R., Bahraini, N. H., Forster, J. E., & Brenner, L. A. (2023). The Unique Association of Posttraumatic Stress Disorder with Hypertension Among Veterans: A Replication of Using Bayesian Estimation and Data from the United States-Veteran Microbiome Project. Psychological Trauma : Theory, Research, Practice and Policy, 15(1), 131–139. https://doi.org/10.1037/tra0001304

Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A., Schäfer, M. S., Mangelsen, E., Fürtig, M. A., ... & Kreutz, R. (2021). Do β-blockers cause depression? Systematic review and meta-analysis of psychiatric adverse events during β-blocker therapy. Hypertension, 77(5), 1539–1548. https://doi.org/10.1161/HYPERTENSIONAHA.120.16590

Rollman, B. L., Anderson, A. M., Rothenberger, S. D., Abebe, K. Z., Ramani, R., Muldoon, M. F., Jakicic, J. M., Herbeck Belnap, B., & Karp, J. F. (2021). Efficacy of Blended Collaborative Care for Patients With Heart Failure and Comorbid Depression: A Randomized Clinical Trial. JAMA Internal Medicine, 181(10), 1369–1380. https://doi.org/10.1001/jamainternmed.2021.4978

Rosenberg, D., Lin, E., Peterson, D., Ludman, E., Von Korff, M., & Katon, W. (2014). Integrated medical care management and behavioral risk factor reduction for multicondition patients: Behavioral outcomes of the TEAMcare trial. General Hospital Psychiatry, 36(2), 129–134. https://doi.org/10.1016/j.genhosppsych.2013.10.017

Rossom, R. C., Solberg, L. I., Magnan, S., Crain, A. L., Beck, A., Coleman, K. J., ... & Unützer, J. (2017). Impact of a national collaborative care initiative for patients with depression and diabetes or cardiovascular disease. Focus, 15(3), 324–332. https://doi.org/10.1176/appi.focus.150304

Santoni, S., Kernic, M. A., Malloy, K., Ali, T., Zhang, Y., Cole, S. A., & Fretts, A. M. (2025). Depression and Incident Hypertension: The Strong Heart Family Study. Preventing Chronic Disease, 22, E06. https://doi.org/10.5888/pcd22.240230

Schaare, H. L., Blöchl, M., Kumral, D., Uhlig, M., Lemcke, L., Valk, S. L., & Villringer, A. (2023). Associations between mental health, blood pressure and the development of hypertension. Nature Communications, 14, 1953. https://doi.org/10.1038/s41467-023-37579-6

Smart Richman, L., Pek, J., Pascoe, E., & Bauer, D. J. (2010). The effects of perceived discrimination on ambulatory blood pressure and affective responses to interpersonal stress modeled over 24 hours. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 29(4), 403–411. https://doi.org/10.1037/a0019045

Spruill, T. M., Shallcross, A. J., Ogedegbe, G., Chaplin, W. F., Butler, M., Palfrey, A., ... & Ravenell, J. (2016). Psychosocial correlates of nocturnal blood pressure dipping in African Americans: the Jackson Heart Study. American Journal of Hypertension, 29(8), 904–912. https://doi.org/10.1093/ajh/hpw008

Srinivasan, K., Mazur, A., Mony, P. K., Whooley, M., & Ekstrand, M. L. (2018). Improving mental health through integration with primary care in rural Karnataka: Study protocol of a cluster randomized control trial. BMC Family Practice, 19(1), 158. https://doi.org/10.1186/s12875-018-0845-z

Stults-Kolehmainen, M. A., & Sinha, R. (2014). The Effects of Stress on Physical Activity and Exercise. Sports Medicine, 44(1), 81–121. https://doi.org/10.1007/s40279-013-0090-5

Tang, R., An, J., Bellows, B. K., Moran, A. E., & Zhang, Y. (2025). Trends in Hypertension Prevalence, Awareness, Treatment, and Control Among US Young Adults, 2003–2023. American Journal of Hypertension, hpaf044. https://doi.org/10.1093/ajh/hpaf044

Ting, E. Y.-C., Yang, A. C., & Tsai, S.-J. (2020). Role of Interleukin-6 in Depressive Disorder. International Journal of Molecular Sciences, 21(6), 2194. https://doi.org/10.3390/ijms21062194

Vivek Singh Chauhan. (2025, May 17). Diabetes, hypertension strongly linked: Study warns of twin epidemics. The Times of India. https://timesofindia.indiatimes.com/city/lucknow/diabetes-hypertension-strongly-linked-study-warns-of-twin-epidemics/articleshow/121220152.cms?utm_source=chatgpt.com

Wartolowska, K. A., & Webb, A. J. S. (2021). Midlife blood pressure is associated with the severity of white matter hyperintensities: Analysis of the UK Biobank cohort study. European Heart Journal, 42(7), 750–757. https://doi.org/10.1093/eurheartj/ehaa756

WHO. (n.d.). Self-care for health and well-being. Retrieved May 22, 2025, from https://www.who.int/health-topics/self-care

WHO. (2020, July 13). HEARTS: Technical package for cardiovascular disease management in primary health care: Risk-based CVD management. https://www.who.int/publications/i/item/9789240001367

WHO. (2021, April 1). HEARTS: Technical package for cardiovascular disease management in primary health care: Tool for the development of a consensus protocol for treatment of hypertension: technical package for cardiovascular disease management in primary health care. https://www.who.int/publications/i/item/WHO-NMH-NVI-19-8

WHO. (2024a, July 24). WHO releases new guidance to help countries integrate self-care within health care. https://www.who.int/news/item/24-07-2024-who-releases-new-guidance-to-help-countries-integrate-self-care-within-health-care

WHO. (2024b, October 10). Mental health of adolescents. https://www.who.int/news-room/fact-sheets/detail/adolescent-mental-health?utm_source=chatgpt.com

Whooley, M. A. (2008). Depressive Symptoms, Health Behaviors, and Risk of Cardiovascular Events in Patients With Coronary Heart Disease. JAMA, 300(20), 2379. https://doi.org/10.1001/jama.2008.711

Wu, S., Zhang, Y., Lu, Y., Yin, Y., Yang, C., Tang, W., Song, T., Tao, X., & Wang, Q. (2025). Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges. Neurobiology of Disease, 211, 106946. https://doi.org/10.1016/j.nbd.2025.106946

Zager Kocjan, G., Avsec, A., & Kavčič, T. (2024). Feeling too low to be active: Physical inactivity mediates the relationship between mental and physical health. Social Science & Medicine, 341, 116546. https://doi.org/10.1016/j.socscimed.2023.116546

Zeng, J., Qiu, Y., Yang, C., Fan, X., Zhou, X., Zhang, C., Zhu, S., Long, Y., Hashimoto, K., Chang, L., & Wei, Y. (2025). Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis. Molecular Psychiatry, 1–13. https://doi.org/10.1038/s41380-025-03003-2

Zhang, H., Xu, Y., & Xu, Y. (2024). Association of diastolic and systolic blood pressure with depression: A cross-sectional study from NHANES 2005-2018. Frontiers in Psychiatry, 15, 1433990. https://doi.org/10.3389/fpsyt.2024.1433990

Zhang, X., & Li, C. (2024). Major depressive disorder increased the risk of hypertension: A Mendelian randomization study. Journal of Affective Disorders, 355, 184–189. https://doi.org/10.1016/j.jad.2024.03.144

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