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Review Article

Young Hearts, Troubled Minds: The Two-Way Link Between Mental Illness and High Blood Pressure Worldwide

Authors

  • Enibokun Theresa Orobator College of Medicine and Veterinary Medicine, University of Edinburgh, UK https://orcid.org/0009-0002-7426-1935

    theresaorobator@gmail.com

  • Wonderful Oluwatoyin Anosike Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, UK https://orcid.org/0009-0008-8587-3156
  • Opeyemi Zainab Malah Lagos State University Teaching Hospital, Lagos, Nigeria
  • Negasi Tsegay Mississippi State Department of Health, Ryan White Part B, Jackson, MS, USA
  • Abdulkareem Misbahudeen Olohuntoyin Kwara State University Teaching Hospital, Ilorin, Nigeria https://orcid.org/0009-0003-2045-4093
  • Precious Esong Sone College of Business, East Carolina University, USA
  • Adeniyi Adewole Aniyeloye Lagos University Teaching Hospital, Lagos, Nigeria

Abstract

Hypertension and common mental disorders crest on the same timeline, from late teens into early midlife, yet healthcare pathways rarely intersect. This review asks two questions: How strongly do mood, anxiety, trauma-related, or severe mental illnesses alter blood-pressure trajectories, and when does elevated pressure echo back on mental health? We searched the biomedical and grey literature (2000-2025) for studies involving 15- to 45-year-olds and distilled converging themes from epidemiology, genetics, mechanistic work, and intervention trials. Consistent evidence shows depressive, anxious, and trauma-related conditions tilt autonomic and inflammatory set points long before a hypertension diagnosis is made. The reverse pathway proves selective: pressure-driven vascular injury, medication effects, and disease labeling nurture later mood disturbance, but early-stage hypertension is often affectively silent. Importantly, collaborative-care models, whether nurse-led in community clinics or delivered through text and app platforms, repeatedly produce parallel gains in mood scores and systolic control. Joint screening and integrated management in young adults, therefore, offer a practical lever to blunt two interwoven epidemics.

Keywords:

Bidirectional Pathways Collaborative Care Hypertension Mental Health Disorders Young Adults

Article information

Journal

Journal of Medical Science, Biology, and Chemistry

Volume (Issue)

2(2), (2025)

Pages

1-14

Published

03-07-2025

How to Cite

Orobator, E. T., Anosike, W. O., Malah, O. Z., Tsegay, N., Olohuntoyin, A. M., Sone, P. E., & Aniyeloye, A. A. (2025). Young Hearts, Troubled Minds: The Two-Way Link Between Mental Illness and High Blood Pressure Worldwide. Journal of Medical Science, Biology, and Chemistry, 2(2), 1-14. https://doi.org/10.69739/jmsbc.v2i2.693

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