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Research Article

Evaluation of Sorghum-Oat-Soybean Ready-To-Use Therapeutic Food (RUTF) on Nutritional Recovery and Biochemical Profiles in Rats

Authors

  • Utah-Iheanyichukwu, Chioma Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
  • Ibeji, Nwokoma Emmanuel Department of Food Science and Technology, Federal University of Technology, Owerri, Imo State, Nigeria
  • Oguizu, Ada Daisy Department of Human Nutrition and Dietetics, Rivers State University of Science and Technology, Rivers State, Nigeria
  • Allison, Trust-Jah Tuaegwuchukwu Interdisciplinary Research Unit, West African Society of Parenteral and Enteral Nutrition (WASPEN), Abuja, Nigeria

    trustjah.allison.186731@unn.edu.ng

Abstract

Mortality due to severe acute malnutrition is one of the leading causes of death especially among children in developing countries. Ready-to-use therapeutic foods (RUTFs) have become the beacon of hope in the new management scene of malnutrition. The study is aimed at the management and assessing the effectiveness of nutritional rehabilitation of malnourished rats. A 33-day study was conducted on 20 Wistar rats which were divided into five different cages randomly and were fed with varying ratios of Sorghum-Oat-Soybean (SOS) Ready-to-Use-Therapeutic Food (RUTF) formulations as well as two controls RUTFS. Results showed pre-starvation body weights of the experimental animals ranged from 104.76g (S1 group) to 106.37g (C0 group). Subsequent to 5 days of starvation, a significant reduction in body weight was observed, with values ranging from 75.05g (S1 group) to 76.11g (S3 group). Following 21 days of nutritional intervention with SOS-RUTF, significant inter-group differences (p < 0.05) were detected in body and organ weights; hemoglobin, cholesterol, and triglyceride levels, ALT, AST, and ALP enzyme activities. The three SOS-RUTFs findings with of different ratios study revealed that SOS-RUTF enhanced formulations brought back the body weight, and organ weight was normal, balanced the biochemical parameters and corrected the hepatic and bone enzyme activities to near normal. These findings have important implications for the treatment of severe acute malnutrition. The study shows that the easily available, inexpensive, and nutritious SOS-RUTF can be used in clinical nutrition and is viable as an option for use in community interventions. This is especially so in developing countries where proper nutritious food is a luxury.

Keywords:

Enzymes Formulated Malnutrition Rats Therapeutic

Article information

Journal

Journal of Agriculture, Aquaculture, and Animal Science

Volume (Issue)

2(1), (2025)

Pages

7-14

Published

12-01-2025

How to Cite

Utah-Iheanyichukwu, C., Ibeji, N. E., Oguizu, A. D., & Allison, T. T. (2025). Evaluation of Sorghum-Oat-Soybean Ready-To-Use Therapeutic Food (RUTF) on Nutritional Recovery and Biochemical Profiles in Rats. Journal of Agriculture, Aquaculture, and Animal Science, 2(1), 7-14. https://doi.org/10.69739/jaaas.v2i1.197

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