Research Article

Ovulation Induction by Used Deslorelin Acetate in Goats During Anestrus Season

Authors

  • Massar Saeb Kadhim Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq

    masar.saab@qu.edu.iq

Abstract

This study determined the inducing of ovulation in local Iraqi goats induction during seasonal anestrus using deslorelin acetate. This study used twenty-four goats that were out of breeding season between January to July 2023. The average weight of goats was 35±5 kg, and aged 2.5 to 3 years. The goats were divided into 2 groups, each one containing 12 goats, all goats synchronized by vaginal sponges (60mg MAP) for 14 days. The treatment injection withdrawal of sponge. The first group received 0.1 mg of intramuscular deslorelin, and the second group (control) received normal saline. The findings of this research were ten does in the first group showed signs of estrus. The results of this study were induction of estrus 83%, Conception rate 90%, litter size 101%, Gestation length 154±2.16 days, and duration of estrus 29.5±4.5 hours were significantly (p≤0.05) in the treated group, While the control group did not show any reproductive performance. Progesterone concentrations were significant (p≤0.05) in all months in the treatment group compared with goats of control. Ultrasonography detection of pregnancy was 100% in treated group by deslorelin in (30 and 60 days) in comparison with control group. The conclusion of the present study was that the use of deslorelin acetate in local Iraqi goats for induction of fertile estrus and ovulation breeding season was greater rates of successful induction of estrus and ovulation and transabdominal transducer at B mode used in the (30-60 days) of pregnancy goats was accurate for early fetal determine.

Keywords:

Deslorelin Estrus Goats Induction Progesterone

Article information

Journal

Journal of Agriculture, Aquaculture, and Animal Science

Volume (Issue)

2(1), (2025)

Pages

70-75

Published

16-03-2025

How to Cite

Kadhim, M. S. (2025). Ovulation Induction by Used Deslorelin Acetate in Goats During Anestrus Season. Journal of Agriculture, Aquaculture, and Animal Science, 2(1), 70-75. https://doi.org/10.69739/jaaas.v2i1.382

References

Abd, A. A., & Ibrahim, N. S. (2023). Induction of oestrus by Sulpiride and measurement of estrogen hormone in Iraqi AwassiEwes during the out of breeding season. The Indian Veterinary Journal, 100(12), 15-18.

Abid, A. A., Younis, L. S., & Rasheed, S. T. (2019). Effect of polymorphism G (129) R in growth differentiation factor 9 gene (GDF9) on Awassi ewes that breed out of season. Biochemical & Cellular Archives, 19(2), 4649-4653. https://doi.org/10.35124/bca.2019.19.2.4649

Al-Mousawe, A. A., & Ibrahim, N. S. (2024). Diagnosis of Pregnancy in Iraqi Awassi Ewes Through Progesterone Hormone Measurement and Ultrasonography Following Induction of Fertile Estrus with Sulpiride. Egyptian Journal of Veterinary Sciences, 55(4), 945-953. https://dx.doi.org/10.21608/ejvs.2023.238362.1629

Ambrose, J. D., Pires, M. F. A., Moreira, F., Diaz, T., Binelli, M., & Thatcher, W. W. (1998). Influence of deslorelin (GnRH-agonist) implant on plasma progesterone, first wave dominant follicle and pregnancy in dairy cattle. Theriogenology, 50(7), 1157-1170. https://doi.org/10.1016/S0093-691X(98)00216-7

Amin, F. A. S. M. (2010). Prenatal Study of testes growth and histological development 2-fetal goat. The Iraqi Journal of Veterinary Medicine, 34(1), 177-185. https://doi.org/10.30539/iraqijvm.v34i1.677

Ardakani, M. S., Toosi, B. K., Azizzadeh, M., & Rajabioun, M. (2022, June). Estimation of gestational age using ultrasonography in Baluchi sheep. In Veterinary Research Forum (Vol. 13, No. 2, p. 257). https://doi.org/10.30466/vrf.2021.131766.3013

Aziz, D. M., & Lazim, E. H. (2012). Transabdominal ultrasonography in standing position for pregnancy diagnosis in Awassi ewes. Small Ruminant Research, 107(2-3), 131-135. https://doi.org/10.1016/j.smallrumres.2012.05.007

Aziz, M. A. (2010). Present status of the world goat populations and their productivity. Lohmann Information, 45(2), 42–52.

Bartolome, J. A., Santos, J. E. P., Pancarci, S. M., Melendez, P., Arteche, A. C. M., Hernandez, O., ... & Thatcher, W. W. (2004). Induction of ovulation in nonlactating dairy cows and heifers using different doses of a deslorelin implant. Theriogenology, 61(2-3), 407-419. https://doi.org/10.1016/S0093-691X(03)00241-3

Bishop, S. C., & Morris, C. A. (2007). Genetics of disease resistance in sheep and goats. Small ruminant research, 70(1), 48-59. https://doi.org/10.1016/j.smallrumres.2007.01.006

Castel, J. M., Ruiz, F. A., Mena, Y., & Sánchez-Rodríguez, M. (2010). Present situation and future perspectives for goat production systems in Spain. Small Ruminant Research, 89(2-3), 207-210. https://doi.org/10.1016/j.smallrumres.2009.12.045

Ferris, R. A., Hatzel, J. N., Lindholm, A. R., Scofield, D. B., & McCue, P. M. (2012). Efficacy of deslorelin acetate (SucroMate) on induction of ovulation in American Quarter Horse mares. Journal of Equine Veterinary Science, 32(5), 285-288. https://doi.org/10.1016/j.jevs.2011.11.007

Garcia, R., Filho, R. A. A., Sitó‐Silva, L., Denadai, R., Codognoto, V., Salgado, L., ... & Oba, E. (2024). Effect of pre‐treatment with deslorelin on the ovarian response of ewes superovulated with FSH. Reproduction in Domestic Animals, 59(8), e14688. https://doi.org/10.1111/rda.14688

Glazar, B. S., McCue, P. M., Bruemmer, J. E., & Squires, E. L. (2004). Deslorelin on Day 8 or 12 postovulation does not luteinize follicles during an artificially maintained diestrous phase in the mare. Theriogenology, 62(1-2), 57-64. https://doi.org/10.1016/j.theriogenology.2003.07.024

Gobello, C. (2007). New GnRH analogs in canine reproduction. Animal Reproduction Science, 100(1-2), 1-13. https://doi.org/10.1016/j.anireprosci.2006.08.024

Gomes, R. G., Oliveira, R. L., de Castro Schutzer, C. G., Barreiros, T. R. R., & Seneda, M. M. (2014). Effect of deslorelin and/or human chorionic gonadotropin on inducing ovulation in mares during the transition period versus ovulatory season. Journal of Equine Veterinary Science, 34(9), 1140-1142. https://doi.org/10.1016/j.jevs.2014.06.015

Greyling, J. P. C., & Van Niekerk, C. H. (1991). Different synchronization techniques in Boer goat does outside the normal breeding season. Small ruminant research, 5(3), 233-243. https://doi.org/10.1016/0921-4488(91)90128-D

Ibrahem, N. S. (2004). Ovarian activity and biometrical study of local Iraq goat. Al-Anbar J. Agric. Sci., 2(2).

Ibrahim, M., Pattanaik, N., Onyango, B., Walker, E., Bledsoe, M., & Sudbrock, C. (2020). Factors affecting goat meat demand and willingness to pay a premium price for domestically produced goat meat in the southern United States. Journal of Food Distribution Research, 51(1), 57-61.

Jiang, G., Stalewski, J., Galyean, R., Dykert, J., Schteingart, C., Broqua, P., ... & Rivier, J. E. (2001). GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6. Journal of medicinal chemistry, 44(3), 453-467. https://doi.org/10.1021/jm0003900

Kähn, W., Achtzehn, J., Kähn, B., Richter, A., Schulz, J., & Wolf, M. (1993). Sonography of pregnancy in sheep. II. Accuracy of transrectal and transcutaneous pregnancy diagnosis. DTW. Deutsche Tierarztliche Wochenschrift, 100(1), 29-31. https://europepmc.org/article/med/8428568

Kanuya, N. L., Kessy, B. M., Nkya, R., & Mujuni, P. F. (2000). Plasma progesterone concentrations and fertility of indigenous small East African goats, bred after treatment with cloprostenol. Small Ruminant Research, 35(2), 157-161. https://doi.org/10.1016/S0921-4488(99)00064-4

Kuru, M., Oral, H., & Kulaksiz, R. (2019). Determination of gestational age by measuring defined embryonic and foetal indices with ultrasonography in Abaza and Gurcu goats. Acta Veterinaria Brno, 87(4), 357-362. https://doi.org/10.2754/avb201887040357

Lazem, I. H., Al-Watar, B. D., & Ibrahim. (2025). Ultrasound detection of fetal sex in goats. Iraqi Journal of Veterinary Sciences, 39(1), 1-7.

Li, L., Lu, S., Ma, Q., Wan, P., Liu, C., Yang, H., ... & Shi, G. (2019). The comparison of reproductive hormone receptor expressions of the sheep ovary and hormone concentrations in two Chinese breeds. Reproduction in Domestic Animals, 54(6), 892-901. https://doi.org/10.1111/rda.13441

Mellado, M., Amaro, J. L., García, J. E., & Lara, L. M. (2000). Factors affecting gestation length in goats and the effect of gestation period on kid survival. The Journal of Agricultural Science, 135(1), 85-89. https://doi.org/10.1017/S0021859699007935

Muhammad, R., & Aziz, D. (2022). Estimation of gestational age in Shami goats based on transabdominal ultrasonographic measurements of fetal parameters. Iraqi Journal of Veterinary Science, 36(4), 839-846.

Musaddin, K., Tan, H. S., Khusahry, M. M., & Jasni, I. (1996). Resumption of postpartum ovarian activity in Malin, Dorset Horn-Malin and Long Tail ewes. Mardi Research Journal, 24, 31-38.

Praharani, L., & Krisnan, R. (2016). A preliminary study on some reproductive traits and heterosis effects of Anglo Nubian and Etawah grade crossbred does. In International Seminar on Livestock Production and Veterinary Technology (pp. 252-260). http://dx.doi.org/10.14334/Proc.Intsem.LPVT-2016-p.252-260

Romano, J. E., & Abella, D. F. (1997). Effect of service on duration of oestrus and ovulation in dairy goats. Animal Reproduction Science, 47(1-2), 107-112. https://doi.org/10.1016/S0378-4320(96)01633-8

Romano, J. E., Alkar, A., & Amstalden, M. (2016). Effect of copulation on estrus duration and ovulation time in goats. Theriogenology, 85(2), 330-334. https://doi.org/10.1016/j.theriogenology.2015.09.021

Santos, J. E. P., Bartolome, J. A., Cerri, R. L. A., Juchem, S. O., Hernandez, O., Trigg, T., & Thatcher, W. W. (2004). Effect of a deslorelin implant in a timed artificial insemination protocol on follicle development, luteal function and reproductive performance of lactating dairy cows. Theriogenology, 61(2-3), 421-435. https://doi.org/10.1016/S0093-691X(03)00242-5

SAS. SAS/STAT users guide for personal computer. Release 9.13. SAS Institute, Inc., Cary, NC, 2010

Singer, L. A., Kumar, M. S. A., Gavin, W., & Ayres, S. L. (2004). Predicting the onset of parturition in the goat by determining progesterone levels by enzyme immunoassay. Small Ruminant Research, 52(3), 203-209. https://doi.org/10.1016/S0921-4488(03)00259-1

Stewart, J., Helms, A., Clark, S., Perry, G., Frieden, E., Lee, A., ... & Pelzer, K. (2023). Use of deslorelin acetate to advance ovulation in goats for timed artificial insemination. Clinical Theriogenology, 15. https://doi.org/10.58292/ct.v15.9382

Tasal, I., Ataman, M. B., Aksoy, M., Kaya, A., Karaca, F., & Tekeli, T. (2005). Estimation of early pregnancy by electrical resistance values of vaginal mucosa in cows and heifers. Revue de Medecine Veterinaire, 156(2), 91-94. https://hdl.handle.net/20.500.12395/19728

Uslu, B. A. R. I. Ş., Şendağ, S., Tasal, I., Gulyuz, F., Ucar, O., & Wehrend, A. (2012). Short-acting Deslorelin Implant (Ovuplant (R)) could not Sufficiently Induce Fertile Cycles of Coloured Mohair Goats in Suckling (Anoestrous) Season. Kafkas Universitesi Veteriner Fakultesi Dergisi, 18(6), 1067-1071. http://doi.org/10.9775/kvfd.2012.7056

Yotov, S. (2005). Diagnostics of early pregnancy in Stara Zagora dairy sheep breed. Bulgarian Journal of Veterinary Medicine, 8(1), 41-45.

Yotov, S. (2007). Early pregnancy diagnostics and determination of offspring number and gender in sheep (Doctoral dissertation, PhD thesis, Stara Zagora).

Zarazaga, L. A., Guzmán, J. L., Domínguez, C., Pérez, M. C., & Prieto, R. (2005). Effect of plane of nutrition on seasonality of reproduction in Spanish Payoya goats. Animal Reproduction Science, 87(3-4), 253-267. https://doi.org/10.1016/j.anireprosci.2004.11.004

Zarkawi, M., & Soukouti, A. (2001). Serum progesterone levels using radioimmunoassay during oestrous cycle of indigenous Damascus does. New Zealand Journal of Agricultural Research, 44(2-3), 165-169. https://doi.org/10.1080/00288233.2001.9513473

Zhao, Y., Zhang, J., Wei, H., Sun, X., Mu, B., Yu, M., & Wang, L. (2010). Efficiency of methods applied for goat estrous synchronization in subtropical monsoonal climate zone of Southwest China. Tropical animal health and production, 42, 1257-1262. https://doi.org/10.1007/s11250-010-9558-6

Downloads

Views

59

Downloads

35