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Review Article

Investigating the Impact of Gut Microbiome Variability on the Pharmacokinetics of Antibiotic Drugs: Systematic Review

Authors

  • Sarhan Rashid College of Dentistry, Wasit University, Wasit, Iraq https://orcid.org/0000-0003-3349-4556

    salzaiyaadi@uowasit.edu.iq

  • Israa Jwad Jaber Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Al-Muthanna, Al-Muthanna, Iraq
  • Asmaa Khadhim Chafla Department of Cosmetic and Laser Techniques, College of Medical and Health Technologies, University of Kut, Wasit, Iraq

Abstract

There is a wide range of bacteria, fungi, and viruses in the gut microbiome living in the digestive system. Over the past decade, more people have acknowledged that the microbiome plays a role in human health, especially how drugs are processed by the body. Because antibiotics are commonly given for bacterial infections, their functioning can be guided by the microbiome. Presence of the gut microbes can impact how a drug is processed and leaves the body, which may contribute to differences in how drugs act, cause side effects, and can be harmful. So far, researchers have discovered only a few ways in which variations in gut microbiome can impact how the body absorbs antibiotics. Overall, review identified 124 scientific studies. Rounding up, 45 studies that satisfied the inclusion criteria were assessed to check for possible biases Researches focused on how the gut microbiome affects the way antibiotic drugs work in people, animals, and laboratory settings. Antibiotic studies that measure parameters such as uptake, breakdown, and removal from the body included in this study. This study summarizes recent studies on the topic and shows how changes in microbiome can change the effects of antibiotics.

Keywords:

Antibiotic Metabolism Drug Absorption Gut Microbiome Microbiome Variability Personalized Medicine Pharmacokinetics

Article information

Journal

Journal of Agriculture, Aquaculture, and Animal Science

Volume (Issue)

2(1), (2025)

Pages

212-220

Published

25-06-2025

How to Cite

Rashid, S., Jaber, I. J., & Chafla, A. K. (2025). Investigating the Impact of Gut Microbiome Variability on the Pharmacokinetics of Antibiotic Drugs: Systematic Review. Journal of Agriculture, Aquaculture, and Animal Science, 2(1), 212-220. https://doi.org/10.69739/jaaas.v2i1.680

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